Strand Life Sciences,
Bangalore
Stand Life Sciences is at the forefront of cancer risk detection, utilizing state-of-the-art genomic technologies to provide comprehensive insights into genetic predispositions for cancer. Their test portfolio is designed to provide the most reliable and thorough genomic insights via:
- Comprehensive Gene Coverage: Genes encode instructions for building proteins, and variations in these sequences can increase cancer risk. Their tests meticulously read each relevant genomic character an average of 400 times, ensuring accuracy and reliability by minimizing the risk of missing critical genetic variations.
- Detailed Variant Analysis: Genetic variants influence gene function and can impact cancer risk. Using advanced bioinformatics tools, they analyze variants spanning hundreds or thousands of characters, distinguishing between benign variations and those contributing to cancer development for precise risk assessment.
- Accurate Variant Classification: Using bioinformatics platforms, they classify variants based on their potential to cause disease. This rigorous process ensures findings are based on current scientific evidence, providing clear insights into cancer risk.
Explore their cancer test portfolio here.
Stand extends its genomic expertise to rare diseases and reproductive disorders. Their comprehensive approach to sequencing and variant analysis ensures that we provide accurate and detailed insights across a variety of genetic conditions, helping to inform better healthcare decisions and personalized treatment plans.
We deal with several sample types in the lab ranging from 96 - 100 samples per day to sometimes few samples for certain specific applications and, we can not wait to batch the samples, so the most important thing with Manta is its flexibility. The fact that you can take from one single sample to up to 32 samples on a go without incurring any significant loss in the yields is extremely crucial for our lab.
A lot of things can be automated in a very seamless manner and yeah, it’s very efficient.
The workflow for the project
1. DNA extraction
After receiving patient blood and saliva samples, the Stand team uses Manta for efficient DNA extraction. This is completed in just 28 minutes on deck.
2. Library preparation
DNA is fragmented and adapters are added, facilitating amplification for sequencing.
3. Sequencing
Generates vast genomic data, revealing genetic variations linked to cancer risk.
4. Genomic Test Panels
Bioinformatics experts analyze data using specialized software, pinpointing cancer-related mutations and interpreting clinical significance.
5. Analysis Report
Summarizes detected variants, clinical implications, and recommendations for patient management, empowering informed decisions on cancer risk assessment, screening, and prevention strategies.
Resources for DNA biobanking processes
DNA extraction from whole blood with Manta
DNA extraction from saliva with Manta
Manta automates the isolation and purification of nucleic acids from biological samples using magnetic-particle-based technology in both diagnostics and research laboratory settings.
Manta utilizes paramagnetic bead technology for purifying nucleic acids. The system has a user-friendly touchscreen interface that hosts various pre-installed protocols.
The Manta workflow is meticulously structured, encompassing three pivotal stages: binding, washing, and elution. Employing magnetic rods affixed to disposable combs, Manta collects beads from the solution and transfers them to subsequent wells. The system’s internal agitation mechanism guarantees thorough sample mixing, while an integrated heating system mitigates alcohol carryover during elution. Furthermore, Manta streamlines sample tracking by enabling elution into barcoded tubes.
Take a peek at how it works in this quick video👇
And if you’re ready to see it in action, let’s set up a demo!
CBWM100-C I Manta – Automated Sample Prep Robot
CBWM068.64 I Cambrian gDNA Isolation from Whole Blood kit pre-filled cartridge for Manta
CBWM096.64 I Cambrian gDNA Isolation from fresh tissue pre-filled cartridge for Manta
CBWM100.64 I Cambrian FFPE DNA Isolation Kit pre-filled cartridge for Manta
CBWM30.64 I Cambrian Viral NA Extraction Kit for Manta
CBWM085.64 I CamOptioma DNA Saliva Extraction kit pre-filled cartridge for Manta
CBWM070.64 I Cambrian Blood RNA isolation Kit
CBWM008-T I 8 Tip combs for Manta
CBWM009.BT I Cambrian 2D-2ML tube
The Strand team was one of the first groups we shared the idea of Manta with, and they've been incredibly supportive as early adopters of our system. We take immense pride in the quality of our buffers that help them conduct their research.
Want to see how Manta can improve your lab workflows? Let’s chat! 🧬✅